SIR Functions Are Required for the Toleration of an Unrepaired Double-Strand Break in a Dispensable Yeast Chromosome

Unrepaired DNA double-strand breaks (DSBs) typically result in G(2) arrest. Cell cycle progression can resume following repair of the DSBs or through adaptation to the checkpoint, even if the damage remains unrepaired. We developed a screen for factors in the yeast Saccharomyces cerevisiae that affe...

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Bibliographic Details
Main Authors: Bennett, Craig B., Snipe, Joyce R., Westmoreland, James W., Resnick, Michael A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC87259/
https://ncbi.nlm.nih.gov/pubmed/11463819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.16.5359-5373.2001
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