Intrasteric Inhibition of ATP Binding Is Not Required To Prevent Unregulated Autophosphorylation or Signaling by the Insulin Receptor

Receptor tyrosine kinases may use intrasteric inhibition to suppress autophosphorylation prior to growth factor stimulation. To test this hypothesis we made an Asp1161Ala mutant in the activation loop that relieved intrasteric inhibition of the unphosphorylated insulin receptor (IR) and its recombin...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Frankel, Mark, Ablooglu, Ararat J., Leone, Joseph W., Rusinova, Elena, Ross, J. B. Alexander, Heinrikson, Robert L., Kohanski, Ronald A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2001
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87081/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11390649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.13.4197-4207.2001
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