Lysosomal association of internalized 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography.

Quantitative electron microscopic autoradiographic studies in cultured human lymphocytes and isolated rat hepatocytes have demonstrated that labeled insulin initially localizes to the plasma membrane and is subsequently internalized to a limited region of the peripheral cytoplasm. When 0.5 nm 125I-i...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Carpentier, J L, Gorden, P, Freychet, P, Le Cam, A, Orci, L
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1979
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC372074/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/447843/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109420
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