Intrasteric Inhibition of ATP Binding Is Not Required To Prevent Unregulated Autophosphorylation or Signaling by the Insulin Receptor

Receptor tyrosine kinases may use intrasteric inhibition to suppress autophosphorylation prior to growth factor stimulation. To test this hypothesis we made an Asp1161Ala mutant in the activation loop that relieved intrasteric inhibition of the unphosphorylated insulin receptor (IR) and its recombin...

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Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Frankel, Mark, Ablooglu, Ararat J., Leone, Joseph W., Rusinova, Elena, Ross, J. B. Alexander, Heinrikson, Robert L., Kohanski, Ronald A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2001
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87081/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11390649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.13.4197-4207.2001
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