Intrasteric Inhibition of ATP Binding Is Not Required To Prevent Unregulated Autophosphorylation or Signaling by the Insulin Receptor

Receptor tyrosine kinases may use intrasteric inhibition to suppress autophosphorylation prior to growth factor stimulation. To test this hypothesis we made an Asp1161Ala mutant in the activation loop that relieved intrasteric inhibition of the unphosphorylated insulin receptor (IR) and its recombin...

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में प्रकाशित:	Mol Cell Biol
मुख्य लेखकों:	Frankel, Mark, Ablooglu, Ararat J., Leone, Joseph W., Rusinova, Elena, Ross, J. B. Alexander, Heinrikson, Robert L., Kohanski, Ronald A.
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Taylor & Francis 2001
विषय:	Cell Growth and Development
ऑनलाइन पहुंच:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC87081/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11390649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.13.4197-4207.2001
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