Sequences Flanking Hypersensitive Sites of the β-Globin Locus Control Region Are Required for Synergistic Enhancement

The major distal regulatory sequence for the β-globin gene locus, the locus control region (LCR), is composed of multiple hypersensitive sites (HSs). Different models for LCR function postulate that the HSs act either independently or synergistically. To test these possibilities, we have constructed...

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Bibliographische Detailangaben
Hauptverfasser: Molete, Joseph M., Petrykowska, Hanna, Bouhassira, Eric E., Feng, Yong-Qing, Miller, Webb, Hardison, Ross C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Transcriptional Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86926/
https://ncbi.nlm.nih.gov/pubmed/11287603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.9.2969-2980.2001
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