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Sequences Flanking Hypersensitive Sites of the β-Globin Locus Control Region Are Required for Synergistic Enhancement

The major distal regulatory sequence for the β-globin gene locus, the locus control region (LCR), is composed of multiple hypersensitive sites (HSs). Different models for LCR function postulate that the HSs act either independently or synergistically. To test these possibilities, we have constructed...

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Publicado no:Mol Cell Biol
Principais autores: Molete, Joseph M., Petrykowska, Hanna, Bouhassira, Eric E., Feng, Yong-Qing, Miller, Webb, Hardison, Ross C.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2001
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86926/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11287603/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.9.2969-2980.2001
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