Distinct Functional Domains of Nibrin Mediate Mre11 Binding, Focus Formation, and Nuclear Localization

The inherited chromosomal instability disorder Nijmegen breakage syndrome (NBS) results from truncating mutations in the NBS1 gene, which encodes the protein nibrin. Nibrin is part of a nuclear multiprotein complex that also contains the DNA repair proteins Mre11 and Rad50. Upon irradiation, this co...

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Argitaratua izan da:	Mol Cell Biol
Egile Nagusiak:	Desai-Mehta, Ami, Cerosaletti, Karen M., Concannon, Patrick
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Taylor & Francis 2001
Gaiak:	DNA Dynamics and Chromosome Structure
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86852/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238951/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.6.2184-2191.2001
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