Distinct Functional Domains of Nibrin Mediate Mre11 Binding, Focus Formation, and Nuclear Localization

The inherited chromosomal instability disorder Nijmegen breakage syndrome (NBS) results from truncating mutations in the NBS1 gene, which encodes the protein nibrin. Nibrin is part of a nuclear multiprotein complex that also contains the DNA repair proteins Mre11 and Rad50. Upon irradiation, this co...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Autores principales:	Desai-Mehta, Ami, Cerosaletti, Karen M., Concannon, Patrick
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2001
Materias:	DNA Dynamics and Chromosome Structure
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86852/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238951/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.6.2184-2191.2001
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