Distinct Functional Domains of Nibrin Mediate Mre11 Binding, Focus Formation, and Nuclear Localization

The inherited chromosomal instability disorder Nijmegen breakage syndrome (NBS) results from truncating mutations in the NBS1 gene, which encodes the protein nibrin. Nibrin is part of a nuclear multiprotein complex that also contains the DNA repair proteins Mre11 and Rad50. Upon irradiation, this co...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Desai-Mehta, Ami, Cerosaletti, Karen M., Concannon, Patrick
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2001
Assuntos:	DNA Dynamics and Chromosome Structure
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86852/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11238951/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.6.2184-2191.2001
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