Inactivation of DNA Mismatch Repair by Increased Expression of Yeast MLH1

Inactivation of DNA mismatch repair by mutation or by transcriptional silencing of the MLH1 gene results in genome instability and cancer predisposition. We recently found (P. V. Shcherbakova and T. A. Kunkel, Mol. Cell. Biol. 19:3177–3183, 1999) that an elevated spontaneous mutation rate can also r...

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Detalhes bibliográficos
Main Authors: Shcherbakova, Polina V., Hall, Mark C., Lewis, Marc S., Bennett, Samuel E., Martin, Karla J., Bushel, Pierre R., Afshari, Cynthia A., Kunkel, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86684/
https://ncbi.nlm.nih.gov/pubmed/11154280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.3.940-951.2001
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