Inactivation of DNA Mismatch Repair by Increased Expression of Yeast MLH1

Inactivation of DNA mismatch repair by mutation or by transcriptional silencing of the MLH1 gene results in genome instability and cancer predisposition. We recently found (P. V. Shcherbakova and T. A. Kunkel, Mol. Cell. Biol. 19:3177–3183, 1999) that an elevated spontaneous mutation rate can also r...

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Autors principals: Shcherbakova, Polina V., Hall, Mark C., Lewis, Marc S., Bennett, Samuel E., Martin, Karla J., Bushel, Pierre R., Afshari, Cynthia A., Kunkel, Thomas A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
DNA Dynamics and Chromosome Structure
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC86684/
https://ncbi.nlm.nih.gov/pubmed/11154280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.3.940-951.2001
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