Generation of a Mouse Model for Arginase II Deficiency by Targeted Disruption of the Arginase II Gene

Mammals express two isoforms of arginase, designated types I and II. Arginase I is a component of the urea cycle, and inherited defects in arginase I have deleterious consequences in humans. In contrast, the physiologic role of arginase II has not been defined, and no deficiencies in arginase II hav...

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Hlavní autoři: Shi, Ou, Morris, Sidney M., Zoghbi, Huda, Porter, Carl W., O'Brien, William E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Mammalian Genetic Models with Minimal or Complex Phenotypes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC86672/
https://ncbi.nlm.nih.gov/pubmed/11154268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.3.811-813.2001
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