Dexamethasone Destabilizes Cyclooxygenase 2 mRNA by Inhibiting Mitogen-Activated Protein Kinase p38

The stability of cyclooxygenase 2 (Cox-2) mRNA is regulated positively by proinflammatory stimuli acting through mitogen-activated protein kinase (MAPK) p38 and negatively by anti-inflammatory glucocorticoids such as dexamethasone. A tetracycline-regulated reporter system was used to investigate mec...

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Detalhes bibliográficos
Main Authors: Lasa, Marina, Brook, Matthew, Saklatvala, Jeremy, Clark, Andrew R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86669/
https://ncbi.nlm.nih.gov/pubmed/11154265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.3.771-780.2001
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