Dexamethasone Causes Sustained Expression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase 1 and Phosphatase-Mediated Inhibition of MAPK p38

The stress-activated protein kinase p38 stabilizes a number of mRNAs encoding inflammatory mediators, such as cyclooxygenase 2 (Cox-2). In HeLa cells the anti-inflammatory glucocorticoid dexamethasone destabilizes Cox-2 mRNA by inhibiting p38 function. Here we demonstrate that this effect is phospha...

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Bibliographische Detailangaben
Hauptverfasser: Lasa, Marina, Abraham, Sonya M., Boucheron, Christine, Saklatvala, Jeremy, Clark, Andrew R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC134716/
https://ncbi.nlm.nih.gov/pubmed/12391149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.22.7802-7811.2002
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