Dexamethasone Causes Sustained Expression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase 1 and Phosphatase-Mediated Inhibition of MAPK p38

The stress-activated protein kinase p38 stabilizes a number of mRNAs encoding inflammatory mediators, such as cyclooxygenase 2 (Cox-2). In HeLa cells the anti-inflammatory glucocorticoid dexamethasone destabilizes Cox-2 mRNA by inhibiting p38 function. Here we demonstrate that this effect is phospha...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Lasa, Marina, Abraham, Sonya M., Boucheron, Christine, Saklatvala, Jeremy, Clark, Andrew R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2002
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134716/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12391149/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.22.7802-7811.2002
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