Dexamethasone Causes Sustained Expression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase 1 and Phosphatase-Mediated Inhibition of MAPK p38

The stress-activated protein kinase p38 stabilizes a number of mRNAs encoding inflammatory mediators, such as cyclooxygenase 2 (Cox-2). In HeLa cells the anti-inflammatory glucocorticoid dexamethasone destabilizes Cox-2 mRNA by inhibiting p38 function. Here we demonstrate that this effect is phospha...

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書誌詳細

出版年:	Mol Cell Biol
主要な著者:	Lasa, Marina, Abraham, Sonya M., Boucheron, Christine, Saklatvala, Jeremy, Clark, Andrew R.
フォーマット:	Artigo
言語:	Inglês
出版事項:	Taylor & Francis 2002
主題:	Cell Growth and Development
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134716/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12391149/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.22.7802-7811.2002
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