The DDE Motif in RAG-1 Is Contributed in trans to a Single Active Site That Catalyzes the Nicking and Transesterification Steps of V(D)J Recombination
The process of assembling immunoglobulin and T-cell receptor genes from variable (V), diversity (D), and joining (J) gene segments, called V(D)J recombination, involves the introduction of DNA breaks at recombination signals. DNA cleavage is catalyzed by RAG-1 and RAG-2 in two chemical steps: first-...
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| Veröffentlicht in: | Mol Cell Biol |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2001
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86595/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11134333/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.2.449-458.2001 |
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