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The DDE Motif in RAG-1 Is Contributed in trans to a Single Active Site That Catalyzes the Nicking and Transesterification Steps of V(D)J Recombination

The process of assembling immunoglobulin and T-cell receptor genes from variable (V), diversity (D), and joining (J) gene segments, called V(D)J recombination, involves the introduction of DNA breaks at recombination signals. DNA cleavage is catalyzed by RAG-1 and RAG-2 in two chemical steps: first-...

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Bibliografiske detaljer
Hovedforfatter: Swanson, Patrick C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86595/
https://ncbi.nlm.nih.gov/pubmed/11134333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.2.449-458.2001
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