The DDE Motif in RAG-1 Is Contributed in trans to a Single Active Site That Catalyzes the Nicking and Transesterification Steps of V(D)J Recombination

The process of assembling immunoglobulin and T-cell receptor genes from variable (V), diversity (D), and joining (J) gene segments, called V(D)J recombination, involves the introduction of DNA breaks at recombination signals. DNA cleavage is catalyzed by RAG-1 and RAG-2 in two chemical steps: first-...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Mol Cell Biol
Autore principale:	Swanson, Patrick C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2001
Soggetti:	DNA Dynamics and Chromosome Structure
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86595/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11134333/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.2.449-458.2001
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!