Long-Distance Control of Origin Choice and Replication Timing in the Human β-Globin Locus Are Independent of the Locus Control Region

DNA replication in the human β-globin locus is subject to long-distance regulation. In murine and human erythroid cells, the human locus replicates in early S phase from a bidirectional origin located near the β-globin gene. This Hispanic thalassemia deletion removes regulatory sequences located ove...

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Bibliografiske detaljer
Main Authors: Cimbora, Daniel M., Schübeler, Dirk, Reik, Andreas, Hamilton, Joan, Francastel, Claire, Epner, Elliot M., Groudine, Mark
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC86017/
https://ncbi.nlm.nih.gov/pubmed/10891496
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