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Long-Distance Control of Origin Choice and Replication Timing in the Human β-Globin Locus Are Independent of the Locus Control Region

DNA replication in the human β-globin locus is subject to long-distance regulation. In murine and human erythroid cells, the human locus replicates in early S phase from a bidirectional origin located near the β-globin gene. This Hispanic thalassemia deletion removes regulatory sequences located ove...

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Detalhes bibliográficos
Main Authors: Cimbora, Daniel M., Schübeler, Dirk, Reik, Andreas, Hamilton, Joan, Francastel, Claire, Epner, Elliot M., Groudine, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC86017/
https://ncbi.nlm.nih.gov/pubmed/10891496
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