Long-Distance Control of Origin Choice and Replication Timing in the Human β-Globin Locus Are Independent of the Locus Control Region

DNA replication in the human β-globin locus is subject to long-distance regulation. In murine and human erythroid cells, the human locus replicates in early S phase from a bidirectional origin located near the β-globin gene. This Hispanic thalassemia deletion removes regulatory sequences located ove...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Cimbora, Daniel M., Schübeler, Dirk, Reik, Andreas, Hamilton, Joan, Francastel, Claire, Epner, Elliot M., Groudine, Mark
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2000
Schlagworte:	DNA Dynamics and Chromosome Structure
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86017/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10891496/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.15.5581-5591.2000
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!