Reconstitution of Human β-Globin Locus Control Region Hypersensitive Sites in the Absence of Chromatin Assembly

The human β-globin genes are regulated by the locus control region (LCR), an element composed of multiple DNase I-hypersensitive sites (HS sites) located 5′ to the genes. Various functional studies indicate that the LCR confers high-level, position-independent, and copy number-dependent expression t...

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Autors principals: Leach, K. M., Nightingale, K., Igarashi, K., Levings, P. P., Engel, J. D., Becker, P. B., Bungert, J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Transcriptional Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC86894/
https://ncbi.nlm.nih.gov/pubmed/11283243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.8.2629-2640.2001
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