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HuD RNA Recognition Motifs Play Distinct Roles in the Formation of a Stable Complex with AU-Rich RNA

Human neuron-specific RNA-binding protein HuD belongs to the family of Hu proteins and consists of two N-terminal RNA recognition motifs (RRM1 and -2), a hinge region, and a C-terminal RRM (RRM3). Hu proteins can bind to AU-rich elements in the 3′ untranslated regions of unstable mRNAs, causing the...

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Main Authors: Park, Sungmin, Myszka, David G., Yu, Michael, Littler, Sarah J., Laird-Offringa, Ite A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC85909/
https://ncbi.nlm.nih.gov/pubmed/10848602
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