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An Evolved RNA Recognition Motif That Suppresses HIV-1 Tat/TAR-Dependent Transcription

Potent and selective recognition and modulation of disease-relevant RNAs remains a daunting challenge. We previously examined the utility of the U1A N-terminal RNA recognition motif as a scaffold for tailoring new RNA hairpin recognition, and showed that as few as one or two mutations can result in...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Crawford, David W., Blakeley, Brett D., Chen, Po-Han, Sherpa, Chringma, Le Grice, Stuart F.J., Laird-Offringa, Ite A., McNaughton, Brian R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5199234/
https://ncbi.nlm.nih.gov/pubmed/27253715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00145
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