Cellular Response to Oncogenic Ras Involves Induction of the Cdk4 and Cdk6 Inhibitor p15(INK4b)

The cell cycle inhibitor p15(INK4b) is frequently inactivated by homozygous deletion together with p16(INK4a) and p19(ARF) in some types of tumors. Although the tumor suppressor capability of p15(INK4b) is still questioned, it has been found to be specifically inactivated by hypermethylation in hema...

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Autors principals: Malumbres, Marcos, Pérez De Castro, Ignacio, Hernández, María I., Jiménez, María, Corral, Teresa, Pellicer, Angel
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC85529/
https://ncbi.nlm.nih.gov/pubmed/10733595
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