Cellular Response to Oncogenic Ras Involves Induction of the Cdk4 and Cdk6 Inhibitor p15(INK4b)

The cell cycle inhibitor p15(INK4b) is frequently inactivated by homozygous deletion together with p16(INK4a) and p19(ARF) in some types of tumors. Although the tumor suppressor capability of p15(INK4b) is still questioned, it has been found to be specifically inactivated by hypermethylation in hema...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Malumbres, Marcos, Pérez De Castro, Ignacio, Hernández, María I., Jiménez, María, Corral, Teresa, Pellicer, Angel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85529/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10733595/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.8.2915-2925.2000
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