Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors

We have introduced a point mutation in the first coding exon of the locus encoding the cyclin-dependent kinase 4 (Cdk4) by homologous recombination in embryonic stem cells. This mutation (replacement of Arg24 by Cys) was first found in patients with hereditary melanoma and renders Cdk4 insensitive t...

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Опубликовано в::	EMBO J
Главные авторы:	Sotillo, Rocío, Dubus, Pierre, Martín, Javier, Cueva, Ernesto de la, Ortega, Sagrario, Malumbres, Marcos, Barbacid, Mariano
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Publishing Group 2001
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11726500/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.23.6637
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