Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

Entry of quiescent cells into the cell cycle is driven by the cyclin D-dependent kinases Cdk4 and Cdk6. These kinases are negatively regulated by the INK4 cell cycle inhibitors. We report the generation of mice defective in P15(INK4b) and P18(INK4c). Ablation of these genes, either alone or in combi...

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Main Authors: Latres, Esther, Malumbres, Marcos, Sotillo, Rocío, Martín, Javier, Ortega, Sagrario, Martín-Caballero, Juan, Flores, Juana María, Cordón-Cardo, Carlos, Barbacid, Mariano
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2000
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC313938/
https://ncbi.nlm.nih.gov/pubmed/10880462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.13.3496
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