Invasive melanoma in Cdk4-targeted mice

Many human tumors harbor mutations that result in deregulation of Cdk4 activity. Most of these mutations involve overexpression of D-type cyclins and inactivation of INK4 inhibitors. In addition, a mutation in the Cdk4 protein has been described in patients with familial melanoma (Wolfel, T., Hauer,...

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Bibliografiske detaljer
Main Authors: Sotillo, Rocío, García, Juan F., Ortega, Sagrario, Martín, Javier, Dubus, Pierre, Barbacid, Mariano, Malumbres, Marcos
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC60867/
https://ncbi.nlm.nih.gov/pubmed/11606789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241338598
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