Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

Entry of quiescent cells into the cell cycle is driven by the cyclin D-dependent kinases Cdk4 and Cdk6. These kinases are negatively regulated by the INK4 cell cycle inhibitors. We report the generation of mice defective in P15(INK4b) and P18(INK4c). Ablation of these genes, either alone or in combi...

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Dades bibliogràfiques

Publicat a:	EMBO J
Autors principals:	Latres, Esther, Malumbres, Marcos, Sotillo, Rocío, Martín, Javier, Ortega, Sagrario, Martín-Caballero, Juan, Flores, Juana María, Cordón-Cardo, Carlos, Barbacid, Mariano
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2000
Matèries:	Articles
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313938/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10880462/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.13.3496
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