Normal Hematopoiesis and Inflammatory Responses Despite Discrete Signaling Defects in Gα15 Knockout Mice

Gα15 activates phospholipase Cβ in response to the greatest variety of agonist-stimulated heptahelical receptors among the four Gq class G-protein α subunits expressed in mammals. Gα15 is primarily expressed in hematopoietic cells in fetal and adult mice. We disrupted the Gα15 gene by homologous rec...

Popoln opis

Bibliografske podrobnosti

izdano v:	Mol Cell Biol
Principais autores:	Davignon, I., Catalina, M. D., Smith, D., Montgomery, J., Swantek, J., Croy, J., Siegelman, M., Wilkie, T. M.
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis 2000
Teme:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85196/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10629036/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.3.797-804.2000
Oznake:	Označite Brez oznak, prvi označite!