Normal Hematopoiesis and Inflammatory Responses Despite Discrete Signaling Defects in Gα15 Knockout Mice

Gα15 activates phospholipase Cβ in response to the greatest variety of agonist-stimulated heptahelical receptors among the four Gq class G-protein α subunits expressed in mammals. Gα15 is primarily expressed in hematopoietic cells in fetal and adult mice. We disrupted the Gα15 gene by homologous rec...

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Detaylı Bibliyografya
Asıl Yazarlar: Davignon, I., Catalina, M. D., Smith, D., Montgomery, J., Swantek, J., Croy, J., Siegelman, M., Wilkie, T. M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2000
Konular:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC85196/
https://ncbi.nlm.nih.gov/pubmed/10629036
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