Bcl-2 and Bcl-X(L) Block Thapsigargin-Induced Nitric Oxide Generation, c-Jun NH(2)-Terminal Kinase Activity, and Apoptosis

The proteins Bcl-2 and Bcl-X(L) prevent apoptosis, but their mechanism of action is unclear. We examined the role of Bcl-2 and Bcl-X(L) in the regulation of cytosolic Ca(2+), nitric oxide production (NO), c-Jun NH(2)-terminal kinase (JNK) activation, and apoptosis in Jurkat T cells. Thapsigargin (TG...

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Main Authors: Srivastava, Rakesh K., Sollott, Steven J., Khan, Leila, Hansford, Richard, Lakatta, Edward G., Longo, Dan L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1999
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC84418/
https://ncbi.nlm.nih.gov/pubmed/10409755
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