The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH(2)-Terminal Kinase

Targeted gene disruption studies have established that the c-Jun NH(2)-terminal kinase (JNK) signaling pathway is required for stress-induced release of mitochondrial cytochrome c and apoptosis. Here we demonstrate that activated JNK is sufficient to induce rapid cytochrome c release and apoptosis....

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Autors principals: Lei, Kui, Nimnual, Anjaruwee, Zong, Wei-Xing, Kennedy, Norman J., Flavell, Richard A., Thompson, Craig B., Bar-Sagi, Dafna, Davis, Roger J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC133923/
https://ncbi.nlm.nih.gov/pubmed/12052897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4929-4942.2002
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