Bcl-XL inhibits membrane permeabilization by competing with Bax.
Although Bcl-XL and Bax are structurally similar, activated Bax forms large oligomers that permeabilize the outer mitochondrial membrane, thereby committing cells to apoptosis, whereas Bcl-XL inhibits this process. Two different models of Bcl-XL function have been proposed. In one, Bcl-XL binds to a...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science (PLoS)
2008-06-01
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| Col·lecció: | PLoS Biology |
| Accés en línia: | http://europepmc.org/articles/PMC2422857?pdf=render |
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