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c-Jun NH(2)-Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1

The protein phosphatase calcineurin is a critical mediator of calcium signals during T-cell activation. One substrate of calcineurin is the transcription factor NFATc1, which is retained in the cytoplasm of quiescent cells. NFATc1 activation requires the translocation of the transcription factor int...

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Auteurs principaux: Chow, Chi-Wing, Dong, Chen, Flavell, Richard A., Davis, Roger J.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2000
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC85971/
https://ncbi.nlm.nih.gov/pubmed/10866678
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