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Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH(2)-terminal kinase activation, and defects in AP-1 transcriptional activity
MKK4 is a member of the mitogen-activated protein kinase kinase group of dual specificity protein kinases that functions as an activator of the c-Jun NH(2)-terminal kinase (JNK) in vitro. To examine the function of MKK4 in vivo, we investigated the effect of targeted disruption of the MKK4 gene. Cro...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences of the USA
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC20312/ https://ncbi.nlm.nih.gov/pubmed/9096336 |
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