Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH(2)-terminal kinase activation, and defects in AP-1 transcriptional activity
MKK4 is a member of the mitogen-activated protein kinase kinase group of dual specificity protein kinases that functions as an activator of the c-Jun NH(2)-terminal kinase (JNK) in vitro. To examine the function of MKK4 in vivo, we investigated the effect of targeted disruption of the MKK4 gene. Cro...
Sparad:
| I publikationen: | Proc Natl Acad Sci U S A |
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| Huvudupphov: | , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
National Academy of Sciences
1997
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20312/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9096336/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.7.3004 |
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