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Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH(2)-terminal kinase activation, and defects in AP-1 transcriptional activity

MKK4 is a member of the mitogen-activated protein kinase kinase group of dual specificity protein kinases that functions as an activator of the c-Jun NH(2)-terminal kinase (JNK) in vitro. To examine the function of MKK4 in vivo, we investigated the effect of targeted disruption of the MKK4 gene. Cro...

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Bibliografski detalji
Glavni autori: Yang, Di, Tournier, Cathy, Wysk, Mark, Lu, Hong-Tao, Xu, Jie, Davis, Roger J., Flavell, Richard A.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences of the USA 1997
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC20312/
https://ncbi.nlm.nih.gov/pubmed/9096336
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