MDM2 Suppresses p73 Function without Promoting p73 Degradation

The newly identified p53 homolog p73 can mimic the transcriptional activation function of p53. We investigated whether p73, like p53, participates in an autoregulatory feedback loop with MDM2. p73 bound to MDM2 both in vivo and in vitro. Wild-type but not mutant MDM2, expressed in human p53 null ost...

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Main Authors: Zeng, Xiaoya, Chen, Lihong, Jost, Christine A., Maya, Ruth, Keller, David, Wang, Xinjiang, Kaelin, William G., Oren, Moshe, Chen, Jiandong, Lu, Hua
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Cell Growth and Development
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC84120/
https://ncbi.nlm.nih.gov/pubmed/10207051
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