MDM2 Promotes Ubiquitination and Degradation of MDMX
The p53 tumor suppressor is regulated by MDM2-mediated ubiquitination and degradation. Mitogenic signals activate p53 by induction of ARF expression, which inhibits p53 ubiquitination by MDM2. Recent studies showed that the MDM2 homolog MDMX is also an important regulator of p53. We present evidence...
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| Publicado no: | Mol Cell Biol |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165735/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12860999/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.15.5113-5121.2003 |
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