Role for Caspase-Mediated Cleavage of Rad51 in Induction of Apoptosis by DNA Damage

We report here that the Rad51 recombinase is cleaved in mammalian cells during the induction of apoptosis by ionizing radiation (IR) exposure. The results demonstrate that IR induces Rad51 cleavage by a caspase-dependent mechanism. Further support for involvement of caspases is provided by the findi...

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Bibliografiske detaljer
Main Authors: Huang, YinYin, Nakada, Shuji, Ishiko, Takatoshi, Utsugisawa, Taiju, Datta, Rakesh, Kharbanda, Surender, Yoshida, Kiyotsugu, Talanian, Robert V., Weichselbaum, Ralph, Kufe, Donald, Yuan, Zhi-Min
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC84093/
https://ncbi.nlm.nih.gov/pubmed/10082566
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