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Protein-Damaging Stresses Activate c-Jun N-Terminal Kinase via Inhibition of Its Dephosphorylation: a Novel Pathway Controlled by HSP72

Various stresses activate the c-Jun N-terminal kinase (JNK), which is involved in the regulation of many aspects of cellular physiology, including apoptosis. Here we demonstrate that in contrast to UV irradiation, heat shock causes little or no stimulation of the JNK-activating kinase SEK1, while kn...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Meriin, Anatoli B., Yaglom, Julia A., Gabai, Vladimir L., Mosser, Dick D., Zon, Leonard, Sherman, Michael Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC84047/
https://ncbi.nlm.nih.gov/pubmed/10082520
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