Inactivation of Dual-Specificity Phosphatases Is Involved in the Regulation of Extracellular Signal-Regulated Kinases by Heat Shock and Hsp72

Extracellular signal-regulated kinase 1 (ERK1) and ERK2 (ERK1/2) dramatically enhance survival of cells exposed to heat shock. Using Cos-7 cells and primary human fibroblasts (IMR90 cells), we demonstrated that heat shock activates ERKs via two distinct mechanisms: stimulation of the ERK-activating...

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Detalhes bibliográficos
Main Authors: Yaglom, Julia, O'Callaghan-Sunol, Cornelia, Gabai, Vladimir, Sherman, Michael Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155207/
https://ncbi.nlm.nih.gov/pubmed/12748284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.11.3813-3824.2003
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