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A [3Fe-4S] cluster and tRNA-dependent aminoacyltransferase BlsK in the biosynthesis of Blasticidin S

Blasticidin S is a peptidyl nucleoside antibiotic. Its biosynthesis involves a cryptic leucylation and two leucylated intermediates, LDBS and LBS, have been found in previous studies. Leucylation has been proposed to be a new self-resistance mechanism during blasticidin S biosynthesis, and the leucy...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Wang, Xiankun, Zhao, Yuchun, Gao, Yaojie, Luo, Xiangkun, Du, Aiqin, Deng, Zixin, Zabriskie, T. Mark, He, Xinyi, Jiang, Ming
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325364/
https://ncbi.nlm.nih.gov/pubmed/34282016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2102318118
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