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Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome
The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S⋅tRNA ribosome complex and performed biochemical and single-molecule FRET experiments to determine the mechanism of action of...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3725078/ https://ncbi.nlm.nih.gov/pubmed/23824292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304922110 |
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