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Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome

The antibiotic blasticidin S (BlaS) is a potent inhibitor of protein synthesis in bacteria and eukaryotes. We have determined a 3.4-Å crystal structure of BlaS bound to a 70S⋅tRNA ribosome complex and performed biochemical and single-molecule FRET experiments to determine the mechanism of action of...

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Bibliographische Detailangaben
Hauptverfasser: Svidritskiy, Egor, Ling, Clarence, Ermolenko, Dmitri N., Korostelev, Andrei A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725078/
https://ncbi.nlm.nih.gov/pubmed/23824292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304922110
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