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The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment
The shelterin protein TPP1 is involved in both recruiting telomerase and stimulating telomerase processivity in human cells. Assessing the in vivo significance of the latter role of TPP1 has been difficult, because TPP1 mutations that perturb telomerase function tend to abolish both telomerase recru...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8325329/ https://ncbi.nlm.nih.gov/pubmed/34282008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024889118 |
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