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The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment

The shelterin protein TPP1 is involved in both recruiting telomerase and stimulating telomerase processivity in human cells. Assessing the in vivo significance of the latter role of TPP1 has been difficult, because TPP1 mutations that perturb telomerase function tend to abolish both telomerase recru...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Sandhu, Ranjodh, Sharma, Madhav, Wei, Derek, Xu, Lifeng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325329/
https://ncbi.nlm.nih.gov/pubmed/34282008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024889118
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