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The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment

The shelterin protein TPP1 is involved in both recruiting telomerase and stimulating telomerase processivity in human cells. Assessing the in vivo significance of the latter role of TPP1 has been difficult, because TPP1 mutations that perturb telomerase function tend to abolish both telomerase recru...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Sandhu, Ranjodh, Sharma, Madhav, Wei, Derek, Xu, Lifeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325329/
https://ncbi.nlm.nih.gov/pubmed/34282008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024889118
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