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The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment
The shelterin protein TPP1 is involved in both recruiting telomerase and stimulating telomerase processivity in human cells. Assessing the in vivo significance of the latter role of TPP1 has been difficult, because TPP1 mutations that perturb telomerase function tend to abolish both telomerase recru...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8325329/ https://ncbi.nlm.nih.gov/pubmed/34282008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024889118 |
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