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The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres

Dyskeratosis Congenita (DC) is a heritable multi-system disorder caused by abnormally short telomeres. Clinically diagnosed by the mucocutaneous symptoms, DC patients are at high risk for bone marrow failure, pulmonary fibrosis, and multiple types of cancers. We have recapitulated the most common DC...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Frank, Amanda K., Tran, Duy C., Qu, Roy W., Stohr, Bradley A., Segal, David J., Xu, Lifeng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521702/
https://ncbi.nlm.nih.gov/pubmed/26230315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005410
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