The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer

The integrated stress response (ISR) is an essential stress-support pathway increasingly recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung adenocarcinoma (LUAD) development, the most common histological type of lung cancer and a leading cause of cancer dea...

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I publikationen:Nat Commun
Huvudupphovsmän: Ghaddar, Nour, Wang, Shuo, Woodvine, Bethany, Krishnamoorthy, Jothilatha, van Hoef, Vincent, Darini, Cedric, Kazimierczak, Urszula, Ah-son, Nicolas, Popper, Helmuth, Johnson, Myriam, Officer, Leah, Teodósio, Ana, Broggini, Massimo, Mann, Koren K., Hatzoglou, Maria, Topisirovic, Ivan, Larsson, Ola, Le Quesne, John, Koromilas, Antonis E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324901/
https://ncbi.nlm.nih.gov/pubmed/34330898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24661-0
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