FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats

FAN1, a DNA structure-specific nuclease, interacts with MLH1, but the repair pathways in which this complex acts are unknown. FAN1 processes DNA interstrand crosslinks (ICLs) and FAN1 variants are modifiers of the neurodegenerative Huntington’s disease (HD), presumably by regulating HD-causing CAG r...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Porro, Antonio, Mohiuddin, Mohiuddin, Zurfluh, Christina, Spegg, Vincent, Dai, Jingqi, Iehl, Florence, Ropars, Virginie, Collotta, Giulio, Fishwick, Keri M., Mozaffari, Nour L., Guérois, Raphaël, Jiricny, Josef, Altmeyer, Matthias, Charbonnier, Jean-Baptiste, Pearson, Christopher E., Sartori, Alessandro A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324060/
https://ncbi.nlm.nih.gov/pubmed/34330701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf7906
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