FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats

FAN1, a DNA structure-specific nuclease, interacts with MLH1, but the repair pathways in which this complex acts are unknown. FAN1 processes DNA interstrand crosslinks (ICLs) and FAN1 variants are modifiers of the neurodegenerative Huntington’s disease (HD), presumably by regulating HD-causing CAG r...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Adv
Prif Awduron: Porro, Antonio, Mohiuddin, Mohiuddin, Zurfluh, Christina, Spegg, Vincent, Dai, Jingqi, Iehl, Florence, Ropars, Virginie, Collotta, Giulio, Fishwick, Keri M., Mozaffari, Nour L., Guérois, Raphaël, Jiricny, Josef, Altmeyer, Matthias, Charbonnier, Jean-Baptiste, Pearson, Christopher E., Sartori, Alessandro A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Association for the Advancement of Science 2021
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324060/
https://ncbi.nlm.nih.gov/pubmed/34330701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf7906
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